Literature summary extracted from

Acevedo, K.; Hayne, D.; McInnes, L.; Noor, A.; Duncan, C.; Moujalled, D.; Volitakis, I.; Rigopoulos, A.; Barnham, K.; Villemagne, V.; White, A.; Donnelly, P.
Effect of structural modifications to glyoxal-bis(thiosemicarbazonato)copper(II) complexes on cellular copper uptake, copper-mediated ATP7A trafficking, and P-glycoprotein mediated efflux (2018), J. Med. Chem., 61, 711-723 .

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
7.2.2.8	glyoxal-bis(N-4,4-pyrolidine-3-thiosemicarbazonato)copper(II)	treatment of SKOV-3 cells with micromolar concentrations leads to trafficking of the endogenous copper transporter ATP7A from the Golgi network to the cell membrane	Homo sapiens
7.2.2.8	glyoxal-bis(N-4-methyl-3-thiosemicarbazonato)copper(II)	treatment of SKOV-3 cells with micromolar concentrations leads to trafficking of the endogenous copper transporter ATP7A from the Golgi network to the cell membrane	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
7.2.2.8	Golgi apparatus	-	Homo sapiens	5794	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
7.2.2.8	Homo sapiens	Q04656	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
7.2.2.8	HEK-293 cell	-	Homo sapiens	-
7.2.2.8	SKOV-3 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)